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Ampicillin sodium for injection

Date:2019-10-10 11:52:54 Number of visits:
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English name: Ampicillin Sodium for Injection
Pinyin: Zhusheyong Anbian Xilinna
[main ingredient] ampicillin sodium
【Properties】 This product is a white crystalline powder.
[Pharmacological action] Pharmacodynamics Ampicillin is a β-lactam antibacterial agent with broad-spectrum antibacterial activity. Sensitive to penicillinase, it is not effective against penicillin-resistant Staphylococcus aureus. Strong against Gram-negative bacteria such as Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella and Pasteurella, but these bacteria are prone to drug resistance; not for Pseudomonas aeruginosa sensitive.
Pharmacokinetics Ampicillin is rapidly absorbed after injection, and the blood concentration is high, but it drops rapidly. The initial concentration of intramuscular or subcutaneous injection was lower. After 10 mg/kg intramuscular injection, the blood concentration reached 14.54 μg/ml in 5 minutes, and the peak plasma concentration was 18.46 μg/ml in 14 minutes. Intramuscular injection, the elimination half-life in horses is 1.21~2.23 hours, and the elimination half-life of buffalo, yellow cattle, pigs and dairy goats is 0.5~1.5 hours. Intravenous injection, the elimination half-life in horses, cattle, sheep and dogs is 0.6~1.6 hours, so the elimination in the body is faster. Probenecid can delay the excretion of this product, increase blood concentration and prolong the half-life.
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